This paper analyses the suitability of Effective Altruism as an ethical frame for the practices of Education for Global Citizenship in the University. According to Effective Altruism, altruistic and solidary practices should be based not only on emotional decisions, but also on a rational analysis to achieve the greatest possible impact for the benefit of third parties. Simultaneously, Universities promote Education for Global Citizenship that includes the development of competencies for the application of ethical principles focused on the improvement of (...) the world as defined in the United Nations 2030 Agenda for Sustainable Development. But the breadth of development problems demands decision criteria to select those causes that can have a greater and better impact. Therefore, Effective Altruism enumerates a reasoned repertoire of decision criteria that could facilitate the application of ethical principles among university global citizenship. (shrink)

IntroductionThis study aimed to evaluate, in adults with mild cognitive impairment, the brain atrophy that may distinguish between three AT biomarker-based profiles, and to determine its clinical value.MethodsStructural MRI was employed to evaluate the volume and cortical thickness differences in MCI patients with different AT profiles, namely, A−T−−: normal AD biomarkers; A+T−−: AD pathologic change; and A+T++: prodromal AD. Sensitivity and specificity of these changes were also estimated.ResultsAn initial atrophy in medial temporal lobe areas was found in the A+T−− and (...) A+T++ groups, spreading toward the parietal and frontal regions in A+T++ patients. These structural changes allowed distinguishing AT profiles within the AD continuum; however, the profiles and their pattern of neurodegeneration were unsuccessful to determine the current clinical status.ConclusionsMRI is useful in the determination of the specific brain structural changes of AT profiles along the AD continuum, allowing differentiation between MCI adults with or without pathological AD biomarkers. (shrink)

Los fondos de inversión se han convertido en los últimos años en un mecanismo frecuente que los clubes de fútbol utilizan para financiar el fichaje de jugadores. Aunque muchos autores han destacado sus efectos beneficiosos al permitir que los clubes adquieran jugadores que de otra manera no podrían conseguir, en este trabajo nos centramos en enfatizar dos problemas que pueden plantear. En primer lugar, hemos tratado de mostrar que pueden generar un progresivo alejamiento de los aficionados. En segundo lugar, a (...) través del dilema del prisionero nos hemos propuesto mostrar que pueden contribuir a aumentar a largo plazo la deuda de los clubes y amenazar el fair play financiero.Investment funds have become in recent years a frequent mechanism football clubs use to finance signing of football players. Although many authors have highlighted their beneficial effects by allowing clubs to acquire players who otherwise they would not get, in this paper we focus on two problems. First, we have tried to show that they can generate a progressive distancing from the fans. Secondly, through the prisoner’s dilemma we intend to show that they can contribute to increasing long-term clubs debt and threaten the financial fair play. (shrink)

Este ensayo ilustra relaciones entre educación, comunicación y complejidad. Se vinculan para complejizar lo que parece sencillo: la comunicación educativa. Su finalidad es mostrar tensiones al comunicar. Enlaza educar y comunicar apoyándose en propuestas de la teoría de la complejidad: códigos, incertidumbre y relatividad. La postura metodológica reúne métodos: fenomenológico-descriptivo, hermenéutico-explicativo, pedagógico-prescriptivo; no los explicita. Primero, describe la tendencia de circunscribir el trabajo universitario al aprendizaje estudiantil; se ilustra para contrastarla con ciencias de la educación adicionales a la psicología. Luego (...) se narra la complejidad de la comunicación docente al humanizar: educar, socializar y jugar. Después se muestra la importancia de justipreciar la comunicación educativa compleja. Complejidad enmarcada en la crisis del paradigma actual. Ulteriormente, ese paradigma se detalla con el recurso de los códigos ideológico, cultural, particular, individual, pedagógico y disciplinar. Se concluye reconociendo la urgencia de humildad, soberbia y eros docente para humanizar(se), conforme a una comunicación educativa compleja. (shrink)

La chaîne de télévision EuroNews est une alternative internationale aux grands médias audiovisuels anglo-saxons. Elle offre un même programme d'information en sept langues qui se veut objectif et anti-nationaliste. Transmettre la même actualité dans des langues différentes et faire travailler des journalistes de différentes cultures, ne sont pourtant pas des tâches faciles. Les choix politiques et organisationnels démontrent qu'EuroNews tente chaque jour de créer une « Europe de l'information ». L'expérience EuroNews prouve aussi que les diversités culturelles et linguistiques ne (...) sont pas des freins à la construction d'un programme d'information communEuroNews is an international alternative to the big English-speaking global news channels. It is unique in that it offers the same programmes in seven languages - French, Spanish, German, Italian, Portuguese, Russian and English - and with a strictly objective and non-nationalistic style and editorial line. Broadcasting the same news in different languages and getting journalists from different cultures to work together harmoniously is not an easy task. Daily editorial decisions show how EuroNews tries to speak to a common European audience. For over a decade now, EuroNews has proved that cultural and linguistic differences are not an obstacle to the creation of a broadly representative coverage of events. (shrink)

El Repertorio bibliográfico sobre Martin Heidegger que se presenta a continuación, reúne la información obtenida de las más de 240 revistas de filosofía disponibles en la Hemeroteca de la Pontificia Universidad Católica del Perú. El Repertorio incluye referencias bibliográficas completas de los artículos, reseñas, estudios críticos, traducciones y otros documentos que abordan la obra del importante pensador alemán hasta el año 2010.

Background: Electroconvulsive therapy is one of the most effective treatments for major depressive disorder. Recently, there has been increasing attention to evaluate the effect of ECT on resting-state functional magnetic resonance imaging. This study aims to compare rs-fMRI of depressive disorder patients with healthy participants, investigate whether pre-ECT dynamic functional network connectivity network estimated from patients rs-fMRI is associated with an eventual ECT outcome, and explore the effect of ECT on brain network states.Method: Resting-state functional magnetic resonance imaging data were (...) collected from 119 patients with depression or depressive disorder, and 61 healthy participants, with an age mean of 52.25 years old. The pre-ECT and post-ECT Hamilton Depression Rating Scale were 25.59 ± 6.14 and 11.48 ± 9.07, respectively. Twenty-four independent components from default mode and cognitive control network were extracted, using group-independent component analysis from pre-ECT and post-ECT rs-fMRI. Then, the sliding window approach was used to estimate the pre-and post-ECT dFNC of each subject. Next, k-means clustering was separately applied to pre-ECT dFNC and post-ECT dFNC to assess three distinct states from each participant. We calculated the amount of time each subject spends in each state, which is called “occupancy rate” or OCR. Next, we compared OCR values between HC and DEP participants. We also calculated the partial correlation between pre-ECT OCRs and HDRS change while controlling for age, gender, and site. Finally, we evaluated the effectiveness of ECT by comparing pre- and post-ECT OCR of DEP and HC participants.Results: The main findings include depressive disorder patients had significantly lower OCR values than the HC group in state 2, where connectivity between cognitive control network and default mode network was relatively higher than other states, Pre-ECT OCR of state, with more negative connectivity between CCN and DMN components, is linked with the HDRS changes. This means that those DEP patients who spent less time in this state showed more HDRS change, and The post-ECT OCR analysis suggested that ECT increased the amount of time DEP patients spent in state 2.Conclusion: Our finding suggests that dynamic functional network connectivity features, estimated from CCN and DMN, show promise as a predictive biomarker of the ECT outcome of DEP patients. Also, this study identifies a possible underlying mechanism associated with the ECT effect on DEP patients. (shrink)

Hipólito Unanue. Bartolomé Herrera. Manuel González Prada. José de la Riva Agüero. José Carlos Mariátegui César Vallejo.

Experiments with cell lines have unveiled the implication of the Rho/Rac family of GTPases in cytoskeletal organization, mitogenesis, and cell migration. However, there have not been adequate animal models to investigate the role of these proteins in more physiological settings. This scenario has changed recently in the case of the T‐cell lineage after the generation of animal models for Rho/Rac family members, their regulators, and effectors. These studies have revealed the implication of these GTPases on multiple regulatory layers of T‐cells, (...) including the coordination of cytoskeletal change, activation of kinase cascades, stimulation of calcium fluxes, and the induction of gene expression. These pathways affect the transition of different T‐cell maturation stages, the positive/negative selection of thymocytes, T‐cell responses to antigens, and the homeostasis of peripheral T‐lymphocytes. Moreover, these animals have revealed interesting cross‐talks between Rho/Rac pathways and other signal transduction routes that participate in lymphocyte responses. BioEssays 24:602–612, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

Tras la pandemia de la covid-19, han aparecido en el contexto hispanohablante tres ensayos que abordan la eclosión de problemas de salud mental en el presente: _Frágiles _(2021), de Remedios Zafra, _Malestamos _(2022), de Javier Padilla y Marta Carmona, y _El murmullo _(2023), de Belén Gopegui. A pesar de la disparidad disciplinar y metodológica de sus autores, sus similitudes son significativas; ante todo, contemplan estos «malestares» atendiendo a sus desencadenantes estructurales. Por un lado, plantean este sufrimiento distintivo de nuestra época (...) como vinculado a las narrativas neoliberales de vida y como una «disfuncionalidad funcional» de las lógicas productivas del capitalismo contemporáneo. Por otro, ofrecen razones para la esperanza, que pasan todas ellas por la búsqueda en colectivo de las condiciones y posibilidades de transformación del presente. (shrink)

Metastasis is one of the clinical parameters that has a strong negative influence on the prognosis of cancer patients. In recent years, significant advances have furthered our understanding of this process at the molecular and biological levels. This paper will discuss recent discoveries relating to the earliest, intra‐tumoral stages of metastasis in cancer cells, specifically focusing on: (i) the development of metastatic traits during primary tumorigenesis; (ii) intrinsic and extrinsic cancer cell programs associated with malignant traits; (iii) the intra‐tumoral migration (...) patterns of cancer cells and the dynamic roles played by the Rho/Rac GTPases and epithelial‐mesenchymal transitions in this process; and (iv) the genetic strategies used by metastatic cancer cells to promote intra‐tumoral cell migration and their subsequent escape to peripheral tissues. Finally, the therapeutic and diagnostic relevance of this information will be discussed, as well as potential future developments. (shrink)

Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is currently known that these GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. In this review, we will provide an overview on the recent advances in this field regarding the mechanism of regulation and signaling, and the roles in vivo of this important GTPase family. BioEssays 29:356–370, 2007. © 2007 Wiley (...) Periodicals, Inc. (shrink)

Na filosofia de Aristóteles, o sentimento de amizade apresenta uma ambivalência com as emoções de rivalidade (philotimia) como a cólera (orgê) e a emulação (zêlos). Neste sentido, este artigo tem como objetivo principal refletir sobre os aspectos emocionais que envolvem a noção de amizade, visando aprofundar a relação entre as emoções de rivalidade e as categorias do desejo em Aristóteles. A produtividade dessas reflexões, aponta que o modo como as diversas relações sociais e a construção do conhecimento desenvolvido, também são (...) emocionais, fato que expõem como condição necessária para o desenvolvimento de aspectos vinculados a formação humana. (shrink)

La relación entre lengua y sexualidad recién ha comenzado a cobrar importancia dentro de los estudios socioculturales. Este trabajo explora las distintas pistas lingüísticas encriptadas en el cuento La búsqueda de Elizabeth, de Marta Pessarrodona, para desenmascarar la velada identidad sexual del personaje central. Un análisis referente al proceso de reconocimiento, búsqueda y aceptación de una identidad sexual no canónica de la protagonista validará los cuatro principios propuestos por Bucholtz y Hall : afloramiento, indexicalidad, relacionalidad y parcialidad.

RESUMENLa melancolía no era desconocida en el mundo clásico. Al contrario, era un ámbito en el que los hombres melancólicos abundaban. Aristóteles, en el texto de Problemas XXX, 1, introduce una precisión acerca de este tema. Dice: Todos los hombres excepcionales son melancólicos. Esta condición obedece, según el Estagirita, a causa físicas –un exceso de bilis negra- y, por tanto, todos aquellos que tengan este exceso participarán también de la excepcionalidad que está reservada a los grandes personajes. Se trata de (...) una afirmación extraña si tenemos en cuenta otros pasajes aristotélicos y que ha provocado interpretaciones diversas y abundantes comentarios. En este trabajo propongo analizar la cuestión de la melancolía en ese texto aristotélico a partir, en primer lugar, de la ubicación del problema en el mundo clásico, avanzando luego hacia una definición de melancolía según el espíritu del Estagirita y su ubicación dentro del corpus doctrinal para finalizar con una conclusión que propone una interpretación base en algunos conceptos de matriz medieval.PALABRAS CLAVEMelancolía - Genialidad - Aristóteles - Tomás de AquinoABSTRACTMelancholy was not unknown in the classic era. On the contrary, that was a time in which melancholic men were many. Aristotle, in the Problems XXX, 1, introduces a precision about this topic. He says: All the exceptional men are melancholic. This condition obeys, according to the Estageira-born, to physical causes – an excess of black bile - and, therefore, all those who have this excess will take part also of the exceptional nature that is reserved to the eminent figures. That is a strange statement if we bear in mind other Aristotelic passages, and it has raised a wide range of interpretations as well as numerous comments. In this work I analyze the question of melancholy in this text, beginning with the contextualization of the problem in the classic world, advancing then towards a definition of melancholy according to the spirit of the Estageira-born and its place inside his doctrinal corpus, finishing with a conclusion that proposes a basic interpretation in some concepts of medieval inspiration.KEYWORDSMelancholy, genius, Aristotle, Thomas Aqu. (shrink)

Very few scientists today question the fact that information, together with matter and energy, is one of the three constructs forming the ontology of the universe. However, there is still a long way to go before in order to establish the interrelations between information and energy and information and matter, as Einstein did between matter and energy. In this paper, after introducing the energy, matter, information model, which covers the three constructs and their relationships, we illustrate real examples—two qualitative and (...) two quantitative—of the interrelations between energy and information. This closes the open question with respect to the interrelationship between energy and information. (shrink)

Se discuten las nociones de filosofía y espiritualidad, tratadas por M. Foucault en La hermenéutica del sujeto, que relacionan el sujeto con la verdad. Si la filosofía del conócete a ti mismo trata la relación cognoscitiva del sujeto con la verdad a la que tiene derecho, entonces la espiritualidad del cuidado de sí trata de la transformación experiencial que requiere la verdad para que el sujeto acceda a ella. Este es el contexto en el que M. Foucault se refiere a (...) M. Heidegger y J. Lacan como los autores que pensaron la relación entre el sujeto y la verdad. Se discute en ambos casos la distinción entre la filosofía y la espiritualidad: en Lacan, porque la experiencia psicoanalítica aparece como vivencia espiritual del cuidado de sí; en Heidegger, porque el Dasein y la verdad como desocultamiento muestran la filosofía como actividad espiritual por excelencia. (shrink)

El principal objetivo de este estudio consiste en dar cuenta de cómo se enmarca la forma de tratamiento nominal marico en el habla de jóvenes universitarios de Caracas, Venezuela, dentro de la Teoría de la cortesía, según la perspectiva ofrecida por los hablantes. Igualmente, se busca documentar qué cambios está presentando en los contextos de uso así como en sus funciones pragmáticas. Los participantes fueron 60 estudiantes universitarios, 30 mujeres y 30 hombres, de 17 a 21 años. Tradicionalmente, la palabra (...) marico se ha usado como agresión verbal vulgar y ha sido, generalmente, considerada un insulto. Luego del análisis cualitativo de los datos, se plantea que esta FTN se halla en una fase de transición de insulto a marcador pragmático anticortés que indica solidaridad dentro de un grupo etario específico y está perdiendo su carácter agraviador. En la actualidad, la juventud caraqueña emplea esta FTN no solo para implicar lazos de amistad, sino para expresar emociones como sorpresa y enojo, crear efectos de intriga, hacer bromas, abrir y cerrar oraciones e, incluso, sustituir otras FTN que nunca han sido consideradas insultos en el español de Venezuela. La metodología empleada fue el cuestionario y el análisis cualitativo de reportes en primera persona. Las variables de edad y sexo son factores determinantes, puesto que parece haber tendencia entre los jóvenes entrevistados a no emplear esta forma nominal con hablantes que están fuera de su grupo etario y las mujeres siguen siendo conservadoras al restringir, más que los hombres, el uso de este vocablo. (shrink)